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The Medicine Chest

Tobacco Mosaic Virus

Item

Title

Tobacco Mosaic Virus

Is Part Of

Biological Sciences
Centre for Infectious Disease Epidemiology and Research

Description

​During the late 19th century, tobacco farmers observed a strange occurrence on the leaves of their tobacco plants. A mosaic pattern of light and dark green (or yellow and green, in some instances) appeared on the leaves of their crops, the presence of which signalled the steady decline in the plant’s growth. ​Because of the lucrative nature of the industry, finding a treatment for this seemingly infectious disease became a priority, with many laboratories working to isolate the cause.​ Bacteria were recognised as the causative agents of many infectious diseases of plants and animals, including humans, in the second half of the 19th century – and the technique of filtration was developed to separate infectious agents from extracts or exudates in order to study these microbes.​ It was whilst utilising this technique that Dmitri Ivanovski, a Russian microbiologist working in the Crimea in 1890, made a surprising discovery. ​Using the Chamberland–filter made from porcelain and designed to trap ordinary bacteria, Ivanovsky discovered that the filtered sap from the diseased plants could continue to transfer the infection to healthy plants ​– an occurrence he attributed to  an agent which must be an exceedingly small parasitic microorganism, invisible even under great magnification.​ It would take another 45 years before the visualisation of this subcellular entity would be formulated with the help of an electron microscope, ​but Ivanovksy, along with the Dutch botanist M.W. Beijerinck, who also and independently, isolated these microbes in his laboratory in 1898, are generally credited for the discovery of viruses.​ The disease which infected the tobacco plants would be aptly called the Tobacco Mosaic Virus, and its identification would signal the initiation of a field of study known as virology.

Creator

Resonances

Chamberlain filter
Old Medical School
Tobacco Mosaic Virus
pattern recognition
Florence Nightingale

Type

Image
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